Drug interactions
Levonorgestrel + Stiripentol
Severity: Moderate
Levonorgestrel and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can inhibit and induce CYP3A4 and other enzymes, so levonorgestrel exposure may rise or fall. Reduced exposure could weaken contraceptive or emergency contraceptive efficacy.
What this interaction means in plain words
Levonorgestrel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol altering levonorgestrel metabolism.
What to do
Advise an additional non-hormonal barrier method during stiripentol use and for a period after stopping. Consider a copper IUD where reliable contraception is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Stiripentol
Frequently asked questions
Can I take Levonorgestrel with Stiripentol?
MediHelp rates the interaction as moderate. Levonorgestrel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can inhibit and induce CYP3A4 and other enzymes, so levonorgestrel exposure may rise or fall. Reduced exposure could weaken contraceptive or emergency contraceptive efficacy.
How serious is the interaction between Levonorgestrel and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal barrier method during stiripentol use and for a period after stopping. Consider a copper IUD where reliable contraception is essential.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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