Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Posaconazole
Severity: Moderate
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase exposure to ethinylestradiol and levonorgestrel, raising hormone-related adverse effects such as nausea, breast tenderness and thromboembolic risk. Contraceptive efficacy is not expected to fall.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of ethinylestradiol and levonorgestrel.
What to do
Monitor for estrogenic and progestogenic adverse effects and blood pressure. Consider a lower-dose or alternative contraceptive if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Posaconazole?
MediHelp rates the interaction as moderate. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may increase exposure to ethinylestradiol and levonorgestrel, raising hormone-related adverse effects such as nausea, breast tenderness and thromboembolic risk. Contraceptive efficacy is not expected to fall.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic and progestogenic adverse effects and blood pressure. Consider a lower-dose or alternative contraceptive if effects occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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