Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Tigecycline
Severity: Minor
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Tigecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been proposed to reduce contraceptive hormone levels by disrupting gut flora, though controlled data show little effect for most agents. Tigecycline labeling mentions possible reduced effectiveness of oral contraceptives.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduced enterohepatic recycling of ethinylestradiol via altered gut flora; not firmly established.
What to do
Advise a backup barrier method during tigecycline therapy and for a short period afterwards. Reinforce adherence to the contraceptive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tigecycline
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Tigecycline?
MediHelp rates the interaction as minor. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Tigecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been proposed to reduce contraceptive hormone levels by disrupting gut flora, though controlled data show little effect for most agents. Tigecycline labeling mentions possible reduced effectiveness of oral contraceptives.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Tigecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise a backup barrier method during tigecycline therapy and for a short period afterwards. Reinforce adherence to the contraceptive.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.
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