Drug interactions
Levorphanol + Lisdexamfetamine
Severity: Moderate
Levorphanol and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is a strong opioid causing sedation and respiratory depression, whereas lisdexamfetamine is a stimulant. Stimulant effects may hide opioid sedation, and the combination may still carry opioid risks; amphetamines may also modestly increase opioid analgesia.
What this interaction means in plain words
Levorphanol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects; no established pharmacokinetic interaction.
What to do
Monitor sedation level and respiratory rate, and do not treat apparent alertness as evidence of safe opioid dosing. Titrate levorphanol to analgesic need.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Levorphanol with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Levorphanol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levorphanol is a strong opioid causing sedation and respiratory depression, whereas lisdexamfetamine is a stimulant. Stimulant effects may hide opioid sedation, and the combination may still carry opioid risks; amphetamines may also modestly increase opioid analgesia.
How serious is the interaction between Levorphanol and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate, and do not treat apparent alertness as evidence of safe opioid dosing. Titrate levorphanol to analgesic need.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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