Drug interactions
Levosalbutamol + Lisdexamfetamine
Severity: Moderate
Levosalbutamol and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sympathomimetic activity, so using them together can add to increases in heart rate and blood pressure. Palpitations, tachyarrhythmias and tremor or agitation may be more pronounced, especially in patients with cardiovascular disease.
What this interaction means in plain words
Levosalbutamol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive adrenergic stimulation, through direct beta-2 agonism by levosalbutamol and indirect catecholamine release by amphetamine.
What to do
Monitor heart rate and blood pressure and ask about palpitations after starting or increasing either drug. Use the lowest effective doses in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Levosalbutamol with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Levosalbutamol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sympathomimetic activity, so using them together can add to increases in heart rate and blood pressure. Palpitations, tachyarrhythmias and tremor or agitation may be more pronounced, especially in patients with cardiovascular disease.
How serious is the interaction between Levosalbutamol and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and ask about palpitations after starting or increasing either drug. Use the lowest effective doses in patients with cardiac disease.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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