Drug interactions
Lidocaine + Oxycodone
Severity: Minor
Lidocaine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine can have sedative effects and may add to opioid CNS depression, but clinically significant interaction is uncommon at usual doses. Topical or local use carries negligible risk.
What this interaction means in plain words
Lidocaine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Oxycodone belongs to Musculoskeletal.
Why it happens
Possible additive CNS depression from systemic lidocaine.
What to do
With intravenous lidocaine, monitor sedation and respiratory status. No action is needed for local or topical use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Oxycodone?
MediHelp rates the interaction as minor. Lidocaine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic lidocaine can have sedative effects and may add to opioid CNS depression, but clinically significant interaction is uncommon at usual doses. Topical or local use carries negligible risk.
How serious is the interaction between Lidocaine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With intravenous lidocaine, monitor sedation and respiratory status. No action is needed for local or topical use.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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