Drug interactions
Lidocaine + Rucaparib
Severity: Minor
Lidocaine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate inhibitor of CYP1A2, one of the enzymes that metabolise lidocaine. Systemic lidocaine exposure may therefore rise modestly, with a higher risk of dose-related toxicity. The effect is unlikely to matter for topical or single local doses.
What this interaction means in plain words
Lidocaine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2-mediated lidocaine metabolism.
What to do
With prolonged or systemic lidocaine, monitor for dizziness, tremor and arrhythmia and lower the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Lidocaine with Rucaparib?
MediHelp rates the interaction as minor. Lidocaine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate inhibitor of CYP1A2, one of the enzymes that metabolise lidocaine. Systemic lidocaine exposure may therefore rise modestly, with a higher risk of dose-related toxicity. The effect is unlikely to matter for topical or single local doses.
How serious is the interaction between Lidocaine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With prolonged or systemic lidocaine, monitor for dizziness, tremor and arrhythmia and lower the dose if needed.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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