Drug interactions
Lidocaine + Ruxolitinib
Severity: Minor
Lidocaine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib is metabolized mainly by CYP3A4, but lidocaine is not a clinically significant CYP3A4 inhibitor. A meaningful increase in ruxolitinib exposure is unlikely at usual lidocaine doses.
What this interaction means in plain words
Lidocaine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Ruxolitinib belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 competition; no established clinically relevant inhibition.
What to do
No dose adjustment is needed; monitor blood counts as routinely recommended for ruxolitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lidocaine and Ruxolitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Lidocaine with Ruxolitinib?
MediHelp rates the interaction as minor. Lidocaine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ruxolitinib is metabolized mainly by CYP3A4, but lidocaine is not a clinically significant CYP3A4 inhibitor. A meaningful increase in ruxolitinib exposure is unlikely at usual lidocaine doses.
How serious is the interaction between Lidocaine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood counts as routinely recommended for ruxolitinib.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
