Drug interactions
Lidocaine + Zileuton
Severity: Moderate
Lidocaine and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is metabolized partly by CYP1A2, so zileuton may increase systemic lidocaine levels. This matters mainly with intravenous or repeated dosing, where neurologic and cardiac toxicity may occur.
What this interaction means in plain words
Lidocaine and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lidocaine belongs to Cardiovascular; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing lidocaine clearance.
What to do
Monitor for signs of lidocaine toxicity such as dizziness, tremor and arrhythmia when given systemically. Reduce the lidocaine infusion rate if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Zileuton?
MediHelp rates the interaction as moderate. Lidocaine and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lidocaine is metabolized partly by CYP1A2, so zileuton may increase systemic lidocaine levels. This matters mainly with intravenous or repeated dosing, where neurologic and cardiac toxicity may occur.
How serious is the interaction between Lidocaine and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of lidocaine toxicity such as dizziness, tremor and arrhythmia when given systemically. Reduce the lidocaine infusion rate if needed.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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