Drug interactions
Lidocaine-prilocaine + Lomitapide
Severity: Minor
Lidocaine-prilocaine and Lomitapide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide exposure rises markedly with strong or moderate CYP3A4 inhibitors, which raises the risk of hepatotoxicity. Topical lidocaine-prilocaine gives low systemic lidocaine levels and is not a meaningful CYP3A4 inhibitor, so a relevant effect is unlikely.
What this interaction means in plain words
Lidocaine-prilocaine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine-prilocaine belongs to Genitourinary; Lomitapide belongs to Cardiovascular.
Why it happens
Lidocaine is a CYP3A4 substrate with negligible inhibitory effect at topical exposure.
What to do
No dose change is needed for standard topical use. Continue routine liver enzyme monitoring for lomitapide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lidocaine-prilocaine with Lomitapide?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Lomitapide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lomitapide exposure rises markedly with strong or moderate CYP3A4 inhibitors, which raises the risk of hepatotoxicity. Topical lidocaine-prilocaine gives low systemic lidocaine levels and is not a meaningful CYP3A4 inhibitor, so a relevant effect is unlikely.
How serious is the interaction between Lidocaine-prilocaine and Lomitapide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed for standard topical use. Continue routine liver enzyme monitoring for lomitapide.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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