Drug interactions
Lidocaine-prilocaine + Sonidegib
Severity: Minor
Lidocaine-prilocaine and Sonidegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is a weak CYP3A4 inhibitor, and the sonidegib label advises against moderate inhibitors, but topical lidocaine-prilocaine produces little systemic exposure. A meaningful rise in sonidegib levels is therefore unlikely.
What this interaction means in plain words
Lidocaine-prilocaine and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine-prilocaine belongs to Genitourinary; Sonidegib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by lidocaine may slightly reduce sonidegib metabolism.
What to do
No change is needed for limited topical use. Monitor for musculoskeletal adverse effects and creatine kinase elevation as usual with sonidegib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Lidocaine-prilocaine with Sonidegib?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Sonidegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is a weak CYP3A4 inhibitor, and the sonidegib label advises against moderate inhibitors, but topical lidocaine-prilocaine produces little systemic exposure. A meaningful rise in sonidegib levels is therefore unlikely.
How serious is the interaction between Lidocaine-prilocaine and Sonidegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed for limited topical use. Monitor for musculoskeletal adverse effects and creatine kinase elevation as usual with sonidegib.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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