Drug interactions
Linagliptin + Lorlatinib
Severity: Minor
Linagliptin and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and P-gp inducer, which may modestly lower linagliptin exposure. Linagliptin is mostly excreted unchanged, so the clinical effect is likely limited.
What this interaction means in plain words
Linagliptin and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A and possibly P-gp, modestly increasing linagliptin clearance.
What to do
Monitor blood glucose and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Linagliptin with Lorlatinib?
MediHelp rates the interaction as minor. Linagliptin and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A inducer and P-gp inducer, which may modestly lower linagliptin exposure. Linagliptin is mostly excreted unchanged, so the clinical effect is likely limited.
How serious is the interaction between Linagliptin and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust antidiabetic therapy if control worsens.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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