Drug interactions
Linagliptin + Pioglitazone
Severity: Minor
Linagliptin and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin exposure is reduced only by strong P-gp/CYP3A4 inducers such as rifampicin. Pioglitazone does not have this effect, and the two drugs are used together routinely.
What this interaction means in plain words
Linagliptin and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Pioglitazone belongs to Endocrine.
Why it happens
No clinically relevant pharmacokinetic interaction; pharmacodynamic effects are complementary.
What to do
No dose adjustment is needed. Monitor glycemic control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Linagliptin with Pioglitazone?
MediHelp rates the interaction as minor. Linagliptin and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Linagliptin exposure is reduced only by strong P-gp/CYP3A4 inducers such as rifampicin. Pioglitazone does not have this effect, and the two drugs are used together routinely.
How serious is the interaction between Linagliptin and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor glycemic control as usual.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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