Drug interactions
Linagliptin + Primidone
Severity: Moderate
Linagliptin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, and its metabolite phenobarbital, induce CYP3A4 and P-glycoprotein, which can lower linagliptin exposure. Reduced linagliptin levels may lead to loss of glycemic control.
What this interaction means in plain words
Linagliptin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and P-glycoprotein by primidone/phenobarbital increases linagliptin clearance and decreases its exposure.
What to do
Monitor blood glucose and HbA1c when starting or stopping primidone. Consider an alternative antidiabetic agent if glycemic control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Linagliptin with Primidone?
MediHelp rates the interaction as moderate. Linagliptin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, and its metabolite phenobarbital, induce CYP3A4 and P-glycoprotein, which can lower linagliptin exposure. Reduced linagliptin levels may lead to loss of glycemic control.
How serious is the interaction between Linagliptin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or stopping primidone. Consider an alternative antidiabetic agent if glycemic control deteriorates.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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