Drug interactions
Linagliptin + Rifabutin
Severity: Moderate
Linagliptin and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and P-gp and may lower linagliptin concentrations, as seen with rifampicin. The reduced exposure may diminish glucose-lowering effect.
What this interaction means in plain words
Linagliptin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induction of CYP3A4 and P-glycoprotein increases linagliptin elimination.
What to do
Monitor glycemic control closely and consider another agent if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Linagliptin with Rifabutin?
MediHelp rates the interaction as moderate. Linagliptin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and P-gp and may lower linagliptin concentrations, as seen with rifampicin. The reduced exposure may diminish glucose-lowering effect.
How serious is the interaction between Linagliptin and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control closely and consider another agent if efficacy falls.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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