Drug interactions
Linagliptin + Somatrogon
Severity: Moderate
Linagliptin and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a long-acting growth hormone, decreases insulin sensitivity and may raise blood glucose, reducing the benefit of linagliptin. Diabetic patients may require treatment adjustment.
What this interaction means in plain words
Linagliptin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance opposes the glucose-lowering effect of linagliptin.
What to do
Monitor glucose and HbA1c when somatrogon is started or the dose is changed, and intensify antidiabetic treatment if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Linagliptin with Somatrogon?
MediHelp rates the interaction as moderate. Linagliptin and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a long-acting growth hormone, decreases insulin sensitivity and may raise blood glucose, reducing the benefit of linagliptin. Diabetic patients may require treatment adjustment.
How serious is the interaction between Linagliptin and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when somatrogon is started or the dose is changed, and intensify antidiabetic treatment if needed.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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