Drug interactions
Linagliptin + Sotorasib
Severity: Minor
Linagliptin and Sotorasib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib has mixed effects on P-gp and CYP3A4, so its net effect on linagliptin is unclear. A clinically important change is unlikely.
What this interaction means in plain words
Linagliptin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin belongs to Endocrine; Sotorasib belongs to Oncology.
Why it happens
Sotorasib modulates P-gp and CYP3A4, and the net effect on linagliptin exposure is not established.
What to do
No empirical adjustment is needed. Monitor glycemic control when starting or stopping sotorasib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Linagliptin with Sotorasib?
MediHelp rates the interaction as minor. Linagliptin and Sotorasib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sotorasib has mixed effects on P-gp and CYP3A4, so its net effect on linagliptin is unclear. A clinically important change is unlikely.
How serious is the interaction between Linagliptin and Sotorasib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed. Monitor glycemic control when starting or stopping sotorasib.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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