Drug interactions
Linagliptin-metformin + Perphenazine
Severity: Moderate
Linagliptin-metformin and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics such as perphenazine can raise blood glucose and cause weight gain, potentially reducing antidiabetic efficacy. The effect is less pronounced than with some atypical agents.
What this interaction means in plain words
Linagliptin-metformin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Antipsychotic-induced insulin resistance and impaired insulin secretion oppose glucose lowering.
What to do
Monitor glucose and HbA1c when perphenazine is started or stopped and adjust antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Linagliptin-metformin with Perphenazine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics such as perphenazine can raise blood glucose and cause weight gain, potentially reducing antidiabetic efficacy. The effect is less pronounced than with some atypical agents.
How serious is the interaction between Linagliptin-metformin and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c when perphenazine is started or stopped and adjust antidiabetic therapy accordingly.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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