Drug interactions
Linagliptin-metformin + Sirolimus
Severity: Moderate
Linagliptin-metformin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus can cause hyperglycemia, dyslipidemia and new-onset diabetes, which may offset the effect of antidiabetic therapy. Glycemic control may worsen.
What this interaction means in plain words
Linagliptin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism, as mTOR inhibition impairs insulin signaling and beta-cell function.
What to do
Monitor blood glucose and HbA1c regularly and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Sirolimus?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus can cause hyperglycemia, dyslipidemia and new-onset diabetes, which may offset the effect of antidiabetic therapy. Glycemic control may worsen.
How serious is the interaction between Linagliptin-metformin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly and intensify antidiabetic therapy if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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