Drug interactions
Linagliptin-metformin + Tacrolimus
Severity: Moderate
Linagliptin-metformin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is diabetogenic and can raise blood glucose, reducing the effect of antidiabetic drugs. It may also impair renal function, which matters for metformin safety.
What this interaction means in plain words
Linagliptin-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism through impaired insulin secretion and insulin resistance, plus possible nephrotoxicity.
What to do
Monitor blood glucose and renal function, and reassess the metformin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Tacrolimus?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus is diabetogenic and can raise blood glucose, reducing the effect of antidiabetic drugs. It may also impair renal function, which matters for metformin safety.
How serious is the interaction between Linagliptin-metformin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and reassess the metformin dose if renal function declines.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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