Drug interactions
Linagliptin-metformin + Trimethoprim
Severity: Moderate
Linagliptin-metformin and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim inhibits renal tubular transporters that secrete metformin, which raises metformin concentrations. This increases the risk of metformin adverse effects including lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Linagliptin-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Trimethoprim belongs to Anti Bacterial.
Why it happens
Inhibition of OCT2 and MATE1/MATE2-K reduces renal tubular secretion of metformin.
What to do
Monitor renal function and for signs of metformin toxicity, and consider reducing the metformin dose, especially with reduced eGFR or prolonged trimethoprim use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Trimethoprim
Frequently asked questions
Can I take Linagliptin-metformin with Trimethoprim?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim inhibits renal tubular transporters that secrete metformin, which raises metformin concentrations. This increases the risk of metformin adverse effects including lactic acidosis, especially with renal impairment.
How serious is the interaction between Linagliptin-metformin and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin toxicity, and consider reducing the metformin dose, especially with reduced eGFR or prolonged trimethoprim use.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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