Drug interactions
Linagliptin-metformin + Vorinostat
Severity: Moderate
Linagliptin-metformin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat commonly causes hyperglycemia, which may reduce the glycemic control achieved with metformin and linagliptin.
What this interaction means in plain words
Linagliptin-metformin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Vorinostat belongs to Oncology.
Why it happens
Drug-related hyperglycemia opposes glucose lowering; the exact mechanism is not well established.
What to do
Monitor blood glucose regularly during vorinostat therapy and adjust antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Linagliptin-metformin with Vorinostat?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat commonly causes hyperglycemia, which may reduce the glycemic control achieved with metformin and linagliptin.
How serious is the interaction between Linagliptin-metformin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly during vorinostat therapy and adjust antidiabetic treatment as needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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