Drug interactions
Lincomycin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Lincomycin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium picosulfate is a prodrug activated by colonic bacteria. Antibiotics that disrupt colonic flora, such as lincomycin, may reduce its activation and weaken bowel cleansing. This could result in inadequate preparation for colonoscopy.
What this interaction means in plain words
Lincomycin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic suppression of colonic bacteria that convert picosulfate to its active diphenolic metabolite.
What to do
Where possible avoid starting lincomycin shortly before bowel preparation. If it is needed, confirm adequate cleansing before the procedure or consider an alternative bowel preparation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lincomycin and Sodium picosulfate / magnesium oxide / anhydrous citric acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lincomycin
- Atracurium + Lincomycin Major
- Cisatracurium + Lincomycin Major
- Lincomycin + Pancuronium Major
- Lincomycin + Rapacuronium Major
- Lincomycin + Rocuronium Major
- Lincomycin + Vecuronium Major
Frequently asked questions
Can I take Lincomycin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Lincomycin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug activated by colonic bacteria. Antibiotics that disrupt colonic flora, such as lincomycin, may reduce its activation and weaken bowel cleansing. This could result in inadequate preparation for colonoscopy.
How serious is the interaction between Lincomycin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible avoid starting lincomycin shortly before bowel preparation. If it is needed, confirm adequate cleansing before the procedure or consider an alternative bowel preparation.
What other medicines interact with Lincomycin?
MediHelp also lists interactions of Lincomycin with, for example, Atracurium, Cisatracurium, Pancuronium. The full list is on the Lincomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
