Drug interactions
Linezolid + Lurasidone
Severity: Moderate
Linezolid and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits MAO and lurasidone has serotonin receptor activity, so serotonin toxicity is theoretically possible, along with additive neuroleptic malignant syndrome features. Reports are rare.
What this interaction means in plain words
Linezolid and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Lurasidone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects from MAO inhibition by linezolid and lurasidone receptor activity.
What to do
Monitor for serotonin toxicity and NMS signs, such as clonus, hyperthermia and rigidity, during linezolid therapy. Discontinue the drugs and give supportive care if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Linezolid with Lurasidone?
MediHelp rates the interaction as moderate. Linezolid and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits MAO and lurasidone has serotonin receptor activity, so serotonin toxicity is theoretically possible, along with additive neuroleptic malignant syndrome features. Reports are rare.
How serious is the interaction between Linezolid and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and NMS signs, such as clonus, hyperthermia and rigidity, during linezolid therapy. Discontinue the drugs and give supportive care if suspected.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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