Drug interactions
Linezolid + Paliperidone
Severity: Moderate
Linezolid and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits monoamine oxidase and paliperidone blocks serotonin 5-HT2A and dopamine D2 receptors. Together they may rarely cause serotonin toxicity or features of neuroleptic malignant syndrome. Documented cases are scarce.
What this interaction means in plain words
Linezolid and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linezolid belongs to Anti Bacterial; Paliperidone belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic effects from MAO inhibition combined with antipsychotic receptor antagonism.
What to do
Monitor for agitation, tremor, clonus, fever, rigidity and autonomic instability throughout linezolid therapy. Discontinue the offending drugs and treat supportively if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Linezolid with Paliperidone?
MediHelp rates the interaction as moderate. Linezolid and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits monoamine oxidase and paliperidone blocks serotonin 5-HT2A and dopamine D2 receptors. Together they may rarely cause serotonin toxicity or features of neuroleptic malignant syndrome. Documented cases are scarce.
How serious is the interaction between Linezolid and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, fever, rigidity and autonomic instability throughout linezolid therapy. Discontinue the offending drugs and treat supportively if symptoms emerge.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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