Drug interactions
Linezolid + Zolmitriptan
Severity: Major
Linezolid and Zolmitriptan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolmitriptan is partly cleared through MAO-A, and its active metabolite as well, so linezolid can raise exposure while adding serotonergic effect. This increases the risk of serotonin syndrome.
What this interaction means in plain words
Linezolid and Zolmitriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Zolmitriptan belongs to Central Nervous System.
Why it happens
Inhibition of MAO-A mediated metabolism of zolmitriptan plus additive serotonergic effects.
What to do
Avoid zolmitriptan during linezolid therapy and for 2 weeks after MAOI exposure as labeled; use an alternative acute migraine therapy and monitor for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Linezolid with Zolmitriptan?
MediHelp rates the interaction as major. Linezolid and Zolmitriptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zolmitriptan is partly cleared through MAO-A, and its active metabolite as well, so linezolid can raise exposure while adding serotonergic effect. This increases the risk of serotonin syndrome.
How serious is the interaction between Linezolid and Zolmitriptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid zolmitriptan during linezolid therapy and for 2 weeks after MAOI exposure as labeled; use an alternative acute migraine therapy and monitor for serotonin toxicity.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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