Drug interactions
Liothyronine + Metformin-sitagliptin
Severity: Moderate
Liothyronine and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone replacement can raise glucose levels and increase insulin requirements, which may weaken the glucose-lowering effect of metformin-sitagliptin. Glycemic control may worsen when liothyronine is started or the dose is increased, and hypoglycemia can occur when it is reduced or stopped.
What this interaction means in plain words
Liothyronine and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liothyronine belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Thyroid hormones increase hepatic glucose output, gut glucose absorption and metabolic rate, which opposes antidiabetic action (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c when liothyronine is started, adjusted or stopped. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Liothyronine and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone replacement can raise glucose levels and increase insulin requirements, which may weaken the glucose-lowering effect of metformin-sitagliptin. Glycemic control may worsen when liothyronine is started or the dose is increased, and hypoglycemia can occur when it is reduced or stopped.
How serious is the interaction between Liothyronine and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when liothyronine is started, adjusted or stopped. Adjust the antidiabetic regimen as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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