Drug interactions
Liothyronine + Rabeprazole
Severity: Minor
Liothyronine and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression may reduce the absorption of oral thyroid hormone, though liothyronine is less dependent on gastric acid than levothyroxine. Data are conflicting and any change in thyroid function is usually small.
What this interaction means in plain words
Liothyronine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liothyronine belongs to Endocrine; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH may modestly impair dissolution and absorption of oral thyroid hormone.
What to do
Check TSH when starting or stopping long-term rabeprazole and adjust the thyroid hormone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Liothyronine and Rabeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Rabeprazole?
MediHelp rates the interaction as minor. Liothyronine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression may reduce the absorption of oral thyroid hormone, though liothyronine is less dependent on gastric acid than levothyroxine. Data are conflicting and any change in thyroid function is usually small.
How serious is the interaction between Liothyronine and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH when starting or stopping long-term rabeprazole and adjust the thyroid hormone dose if needed.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
