Drug interactions
Liothyronine + Theophylline
Severity: Minor
Liothyronine and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid status alters theophylline clearance: hypothyroidism lowers it and restoring euthyroidism increases it. Starting thyroid hormone in a hypothyroid patient may lower theophylline levels and reduce effect.
What this interaction means in plain words
Liothyronine and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liothyronine belongs to Endocrine; Theophylline belongs to Respiratory.
Why it happens
Thyroid hormone increases the metabolic clearance of theophylline as the metabolic rate normalizes.
What to do
Monitor theophylline levels and clinical response when thyroid replacement is initiated or its dose is changed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Theophylline?
MediHelp rates the interaction as minor. Liothyronine and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thyroid status alters theophylline clearance: hypothyroidism lowers it and restoring euthyroidism increases it. Starting thyroid hormone in a hypothyroid patient may lower theophylline levels and reduce effect.
How serious is the interaction between Liothyronine and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline levels and clinical response when thyroid replacement is initiated or its dose is changed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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