Drug interactions
Liposomal doxorubicin + Mitotane
Severity: Moderate
Liposomal doxorubicin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and may reduce doxorubicin exposure, with possible loss of efficacy. The induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Liposomal doxorubicin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing doxorubicin metabolism.
What to do
Monitor tumor response and consider whether alternative therapy is appropriate. Account for persistent induction after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Liposomal doxorubicin with Mitotane?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and may reduce doxorubicin exposure, with possible loss of efficacy. The induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Liposomal doxorubicin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider whether alternative therapy is appropriate. Account for persistent induction after mitotane discontinuation.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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