Drug interactions
Liposomal doxorubicin + Paclitaxel
Severity: Moderate
Liposomal doxorubicin and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel may increase exposure to doxorubicin, though data for the liposomal form are limited. This could increase myelosuppression, mucositis and cardiotoxicity.
What this interaction means in plain words
Liposomal doxorubicin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Paclitaxel may reduce doxorubicin clearance via effects on biliary efflux transporters.
What to do
Monitor blood counts and cardiac function, and observe cumulative anthracycline dose limits. Follow protocol sequencing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Liposomal doxorubicin with Paclitaxel?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel may increase exposure to doxorubicin, though data for the liposomal form are limited. This could increase myelosuppression, mucositis and cardiotoxicity.
How serious is the interaction between Liposomal doxorubicin and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and observe cumulative anthracycline dose limits. Follow protocol sequencing.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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