Drug interactions
Liposomal doxorubicin + Quinidine
Severity: Moderate
Liposomal doxorubicin and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and could raise exposure to doxorubicin, with a potential for greater myelosuppression and cardiotoxicity. For the liposomal formulation, which has a different distribution, the clinical relevance is uncertain.
What this interaction means in plain words
Liposomal doxorubicin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein efflux by quinidine may increase doxorubicin tissue and systemic exposure.
What to do
Monitor blood counts and cardiac function, and consider an alternative to quinidine; quinidine also adds QT-prolonging risk, so check an ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Liposomal doxorubicin with Quinidine?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-glycoprotein and could raise exposure to doxorubicin, with a potential for greater myelosuppression and cardiotoxicity. For the liposomal formulation, which has a different distribution, the clinical relevance is uncertain.
How serious is the interaction between Liposomal doxorubicin and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider an alternative to quinidine; quinidine also adds QT-prolonging risk, so check an ECG.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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