Drug interactions
Liposomal doxorubicin + Verapamil
Severity: Moderate
Liposomal doxorubicin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and CYP3A4 and can raise doxorubicin exposure, and it has been linked to greater anthracycline cardiotoxicity. Verapamil's own negative inotropic effect adds to cardiac risk.
What this interaction means in plain words
Liposomal doxorubicin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits P-glycoprotein and CYP3A4, reducing doxorubicin efflux and clearance.
What to do
Monitor cardiac function (LVEF) and blood counts, and prefer a non-interacting antihypertensive or antiarrhythmic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Liposomal doxorubicin with Verapamil?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-glycoprotein and CYP3A4 and can raise doxorubicin exposure, and it has been linked to greater anthracycline cardiotoxicity. Verapamil's own negative inotropic effect adds to cardiac risk.
How serious is the interaction between Liposomal doxorubicin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cardiac function (LVEF) and blood counts, and prefer a non-interacting antihypertensive or antiarrhythmic when possible.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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