Drug interactions
Liraglutide + Quetiapine
Severity: Moderate
Liraglutide and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can raise blood glucose and promote weight gain, which can offset the glucose-lowering action of liraglutide. Glycemic control may deteriorate after quetiapine is started or its dose is increased.
What this interaction means in plain words
Liraglutide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: antipsychotic-related insulin resistance and metabolic effects oppose GLP-1 receptor agonist glucose lowering.
What to do
Monitor fasting glucose and HbA1c, and weight, when quetiapine is started or adjusted. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Quetiapine?
MediHelp rates the interaction as moderate. Liraglutide and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can raise blood glucose and promote weight gain, which can offset the glucose-lowering action of liraglutide. Glycemic control may deteriorate after quetiapine is started or its dose is increased.
How serious is the interaction between Liraglutide and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c, and weight, when quetiapine is started or adjusted. Adjust the antidiabetic regimen as needed.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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