Drug interactions
Liraglutide + Repaglinide
Severity: Moderate
Liraglutide and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide combined with repaglinide increases the risk of hypoglycemia because both stimulate insulin secretion. The risk is greatest when liraglutide is started or the dose is increased.
What this interaction means in plain words
Liraglutide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on insulin secretion.
What to do
Consider reducing the repaglinide dose when starting liraglutide and monitor blood glucose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Repaglinide?
MediHelp rates the interaction as moderate. Liraglutide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide combined with repaglinide increases the risk of hypoglycemia because both stimulate insulin secretion. The risk is greatest when liraglutide is started or the dose is increased.
How serious is the interaction between Liraglutide and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the repaglinide dose when starting liraglutide and monitor blood glucose.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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