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Drug interactions

Liraglutide + Thioridazine

Severity: Minor

Liraglutide and Thioridazine: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Phenothiazines can alter glucose handling, so thioridazine may reduce glycemic control in patients treated with liraglutide. The effect is variable and generally modest. Weight gain from the antipsychotic may also work against the metabolic goals of treatment.

What this interaction means in plain words

Liraglutide and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Liraglutide belongs to Endocrine; Thioridazine belongs to Central Nervous System.

Evidence level: Low

Why it happens

Antipsychotic-related impaired glucose tolerance and weight gain opposing the glucose-lowering effect of liraglutide.

What to do

Monitor blood glucose and HbA1c after starting or changing thioridazine. Adjust the antidiabetic regimen if control worsens.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Liraglutide with Thioridazine?

MediHelp rates the interaction as minor. Liraglutide and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can alter glucose handling, so thioridazine may reduce glycemic control in patients treated with liraglutide. The effect is variable and generally modest. Weight gain from the antipsychotic may also work against the metabolic goals of treatment.

How serious is the interaction between Liraglutide and Thioridazine?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing thioridazine. Adjust the antidiabetic regimen if control worsens.

What other medicines interact with Thioridazine?

MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.

Full monographs, dosing and an interaction checker in the MediHelp app

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