Drug interactions
Liraglutide + Tolbutamide
Severity: Moderate
Liraglutide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide enhances glucose-dependent insulin secretion and tolbutamide stimulates insulin release directly. Together they increase the risk of hypoglycemia, which can be severe.
What this interaction means in plain words
Liraglutide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects from combined insulin secretion stimulation.
What to do
Consider reducing the tolbutamide dose when starting liraglutide and monitor blood glucose closely. Educate the patient on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Tolbutamide?
MediHelp rates the interaction as moderate. Liraglutide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide enhances glucose-dependent insulin secretion and tolbutamide stimulates insulin release directly. Together they increase the risk of hypoglycemia, which can be severe.
How serious is the interaction between Liraglutide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolbutamide dose when starting liraglutide and monitor blood glucose closely. Educate the patient on hypoglycemia.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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