Drug interactions
Lisdexamfetamine + Lithium
Severity: Moderate
Lisdexamfetamine and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase release of serotonin as well as catecholamines, and lithium enhances serotonergic function, so serotonin syndrome is possible. Lithium may also blunt the stimulant effect of amphetamines.
What this interaction means in plain words
Lisdexamfetamine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Why it happens
Additive serotonergic activity.
What to do
Start lisdexamfetamine at a low dose and titrate slowly while watching for agitation, tremor, hyperthermia and autonomic instability. Stop the serotonergic drugs and treat if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Lithium?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase release of serotonin as well as catecholamines, and lithium enhances serotonergic function, so serotonin syndrome is possible. Lithium may also blunt the stimulant effect of amphetamines.
How serious is the interaction between Lisdexamfetamine and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start lisdexamfetamine at a low dose and titrate slowly while watching for agitation, tremor, hyperthermia and autonomic instability. Stop the serotonergic drugs and treat if serotonin syndrome develops.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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