Drug interactions
Lisdexamfetamine + Lofepramine
Severity: Major
Lisdexamfetamine and Lofepramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic partly converted to desipramine, blocks norepinephrine reuptake. With amphetamine from lisdexamfetamine it may cause exaggerated hypertension, tachycardia and arrhythmia.
What this interaction means in plain words
Lisdexamfetamine and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Blocked norepinephrine reuptake gives additive adrenergic effects and may alter amphetamine uptake.
What to do
Prefer an alternative. If used together, titrate slowly and monitor blood pressure, heart rate and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Lofepramine?
MediHelp rates the interaction as major. Lisdexamfetamine and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofepramine, a tricyclic partly converted to desipramine, blocks norepinephrine reuptake. With amphetamine from lisdexamfetamine it may cause exaggerated hypertension, tachycardia and arrhythmia.
How serious is the interaction between Lisdexamfetamine and Lofepramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative. If used together, titrate slowly and monitor blood pressure, heart rate and ECG.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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