Drug interactions
Lisdexamfetamine + Loprazolam
Severity: Minor
Lisdexamfetamine and Loprazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loprazolam is a benzodiazepine hypnotic and lisdexamfetamine is a stimulant, so their effects on arousal oppose one another. Perceived alertness may be misleading because psychomotor impairment from the benzodiazepine can persist.
What this interaction means in plain words
Lisdexamfetamine and Loprazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no pharmacokinetic interaction is established.
What to do
Advise patients to avoid driving until the combined response is known. Review the need for each drug if sleep or anxiety worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Loprazolam?
MediHelp rates the interaction as minor. Lisdexamfetamine and Loprazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loprazolam is a benzodiazepine hypnotic and lisdexamfetamine is a stimulant, so their effects on arousal oppose one another. Perceived alertness may be misleading because psychomotor impairment from the benzodiazepine can persist.
How serious is the interaction between Lisdexamfetamine and Loprazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving until the combined response is known. Review the need for each drug if sleep or anxiety worsens.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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