Drug interactions
Lisdexamfetamine + Marijuana
Severity: Moderate
Lisdexamfetamine and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause sedation, impaired cognition and tachycardia, while lisdexamfetamine is a stimulant with its own cardiovascular effects. Together they may add to tachycardia, anxiety or psychosis risk in susceptible people, and alertness may mask cannabis impairment.
What this interaction means in plain words
Lisdexamfetamine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects with additive sympathomimetic cardiovascular effects; no established pharmacokinetic mechanism.
What to do
Advise against combined use and monitor heart rate, blood pressure and psychiatric symptoms. Counsel about impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Marijuana?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can cause sedation, impaired cognition and tachycardia, while lisdexamfetamine is a stimulant with its own cardiovascular effects. Together they may add to tachycardia, anxiety or psychosis risk in susceptible people, and alertness may mask cannabis impairment.
How serious is the interaction between Lisdexamfetamine and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against combined use and monitor heart rate, blood pressure and psychiatric symptoms. Counsel about impaired driving.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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