Drug interactions
Lisdexamfetamine + Meprobamate
Severity: Minor
Lisdexamfetamine and Meprobamate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic and lisdexamfetamine is a stimulant, so they have opposing effects on alertness. The stimulant may mask meprobamate sedation, and the net effect is unpredictable.
What this interaction means in plain words
Lisdexamfetamine and Meprobamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no pharmacokinetic interaction is established.
What to do
Counsel on driving and machinery risks and monitor response. Adjust doses if oversedation or overstimulation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Meprobamate?
MediHelp rates the interaction as minor. Lisdexamfetamine and Meprobamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meprobamate is a sedative-anxiolytic and lisdexamfetamine is a stimulant, so they have opposing effects on alertness. The stimulant may mask meprobamate sedation, and the net effect is unpredictable.
How serious is the interaction between Lisdexamfetamine and Meprobamate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on driving and machinery risks and monitor response. Adjust doses if oversedation or overstimulation occurs.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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