Drug interactions
Lisdexamfetamine + Metaproterenol
Severity: Moderate
Lisdexamfetamine and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sympathomimetic activity, so combined use may increase heart rate and blood pressure and cause tremor, palpitations and nervousness. The risk is greater with underlying cardiovascular disease.
What this interaction means in plain words
Lisdexamfetamine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation from amphetamine-induced catecholamine release and direct beta-2 agonism.
What to do
Monitor heart rate, blood pressure and arrhythmia symptoms. Use the lowest effective bronchodilator dose in patients with heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Metaproterenol?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sympathomimetic activity, so combined use may increase heart rate and blood pressure and cause tremor, palpitations and nervousness. The risk is greater with underlying cardiovascular disease.
How serious is the interaction between Lisdexamfetamine and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and arrhythmia symptoms. Use the lowest effective bronchodilator dose in patients with heart disease.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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