Drug interactions
Lisdexamfetamine + Methoxyflurane
Severity: Major
Lisdexamfetamine and Methoxyflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane can sensitize the heart to catecholamines. With amphetamine from lisdexamfetamine this may provoke ventricular arrhythmias and hypertension.
What this interaction means in plain words
Lisdexamfetamine and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Myocardial sensitization to catecholamines by the anesthetic plus amphetamine-driven catecholamine release.
What to do
Avoid concurrent use where possible and monitor ECG and blood pressure closely if anesthesia or analgesia is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Methoxyflurane?
MediHelp rates the interaction as major. Lisdexamfetamine and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane can sensitize the heart to catecholamines. With amphetamine from lisdexamfetamine this may provoke ventricular arrhythmias and hypertension.
How serious is the interaction between Lisdexamfetamine and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and monitor ECG and blood pressure closely if anesthesia or analgesia is needed.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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