Drug interactions
Lisdexamfetamine + Methylergonovine
Severity: Major
Lisdexamfetamine and Methylergonovine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylergonovine causes strong uterine and vascular smooth muscle contraction, and amphetamine adds sympathomimetic pressor effects. The combination may produce hypertension and vasospasm.
What this interaction means in plain words
Lisdexamfetamine and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive vasoconstriction from ergot receptor agonism and amphetamine-induced catecholamine release.
What to do
Avoid if possible; if methylergonovine is needed for postpartum hemorrhage, monitor blood pressure closely and watch for ischemic symptoms or severe headache.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Methylergonovine?
MediHelp rates the interaction as major. Lisdexamfetamine and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylergonovine causes strong uterine and vascular smooth muscle contraction, and amphetamine adds sympathomimetic pressor effects. The combination may produce hypertension and vasospasm.
How serious is the interaction between Lisdexamfetamine and Methylergonovine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if methylergonovine is needed for postpartum hemorrhage, monitor blood pressure closely and watch for ischemic symptoms or severe headache.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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