Drug interactions
Lisdexamfetamine + Olanzapine
Severity: Moderate
Lisdexamfetamine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics block dopamine receptors while amphetamines increase dopaminergic activity, so each may reduce the other's therapeutic effect. Olanzapine is also sedating, whereas lisdexamfetamine is stimulating. The combination is used clinically in some patients and is typically manageable.
What this interaction means in plain words
Lisdexamfetamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects at dopamine receptors; stimulants may worsen psychosis while D2 blockade may blunt stimulant effects.
What to do
Monitor for psychotic symptom worsening, sedation and diminished stimulant efficacy. Adjust doses based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Lisdexamfetamine with Olanzapine?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics block dopamine receptors while amphetamines increase dopaminergic activity, so each may reduce the other's therapeutic effect. Olanzapine is also sedating, whereas lisdexamfetamine is stimulating. The combination is used clinically in some patients and is typically manageable.
How serious is the interaction between Lisdexamfetamine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for psychotic symptom worsening, sedation and diminished stimulant efficacy. Adjust doses based on clinical response.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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