Drug interactions
Lisdexamfetamine + Opium tincture
Severity: Moderate
Lisdexamfetamine and Opium tincture: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture is an opioid causing sedation and respiratory depression, while lisdexamfetamine is a stimulant. Stimulant activity may hide opioid sedation, but respiratory depression risk remains.
What this interaction means in plain words
Lisdexamfetamine and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects; no established pharmacokinetic interaction.
What to do
Monitor sedation and respiratory rate, and dose opioid on clinical need rather than on apparent alertness. Counsel on impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Opium tincture?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Opium tincture can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture is an opioid causing sedation and respiratory depression, while lisdexamfetamine is a stimulant. Stimulant activity may hide opioid sedation, but respiratory depression risk remains.
How serious is the interaction between Lisdexamfetamine and Opium tincture?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and dose opioid on clinical need rather than on apparent alertness. Counsel on impaired driving.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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