Drug interactions
Lisdexamfetamine + Phendimetrazine
Severity: Major
Lisdexamfetamine and Phendimetrazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sympathomimetic anorectic or stimulant drugs, so combining them gives additive stimulation. This can cause hypertension, tachycardia, insomnia, anxiety and arrhythmia, and adds to misuse potential.
What this interaction means in plain words
Lisdexamfetamine and Phendimetrazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive sympathomimetic effects from release of norepinephrine and dopamine.
What to do
Avoid concurrent use of two stimulant anorectic agents where possible. If unavoidable, monitor blood pressure, heart rate and psychiatric symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisdexamfetamine and Phendimetrazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Phendimetrazine?
MediHelp rates the interaction as major. Lisdexamfetamine and Phendimetrazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are sympathomimetic anorectic or stimulant drugs, so combining them gives additive stimulation. This can cause hypertension, tachycardia, insomnia, anxiety and arrhythmia, and adds to misuse potential.
How serious is the interaction between Lisdexamfetamine and Phendimetrazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two stimulant anorectic agents where possible. If unavoidable, monitor blood pressure, heart rate and psychiatric symptoms.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
