Drug interactions
Lisdexamfetamine + Phenobarbital
Severity: Moderate
Lisdexamfetamine and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is a sedative anticonvulsant and lisdexamfetamine is a stimulant, so their effects on alertness oppose each other. Stimulants may lower seizure threshold, which is relevant in patients treated for epilepsy.
What this interaction means in plain words
Lisdexamfetamine and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects; stimulants may lower seizure threshold, opposing anticonvulsant effect.
What to do
Monitor seizure control and sedation, and review anticonvulsant dosing if seizures increase. Counsel on driving risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Phenobarbital?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is a sedative anticonvulsant and lisdexamfetamine is a stimulant, so their effects on alertness oppose each other. Stimulants may lower seizure threshold, which is relevant in patients treated for epilepsy.
How serious is the interaction between Lisdexamfetamine and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation, and review anticonvulsant dosing if seizures increase. Counsel on driving risks.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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