Drug interactions
Lisdexamfetamine + Quazepam
Severity: Minor
Lisdexamfetamine and Quazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic while lisdexamfetamine is a stimulant, so they have opposing effects on alertness. The stimulant may mask sedation without removing psychomotor impairment from the benzodiazepine. Both also carry abuse and dependence potential.
What this interaction means in plain words
Lisdexamfetamine and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS effects (GABA-A enhancement versus catecholamine release) with no established pharmacokinetic interaction.
What to do
Warn the patient that impairment may persist despite feeling alert, and avoid driving until response is known. Review ongoing need for each agent and dose timing to limit insomnia and next-day sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Quazepam?
MediHelp rates the interaction as minor. Lisdexamfetamine and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quazepam is a long-acting benzodiazepine hypnotic while lisdexamfetamine is a stimulant, so they have opposing effects on alertness. The stimulant may mask sedation without removing psychomotor impairment from the benzodiazepine. Both also carry abuse and dependence potential.
How serious is the interaction between Lisdexamfetamine and Quazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient that impairment may persist despite feeling alert, and avoid driving until response is known. Review ongoing need for each agent and dose timing to limit insomnia and next-day sedation.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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